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- It is a genetic condition
- Males are more affected than females
- Seizures occur in about 15% of males and 5% of females
- 1/3 individuals have similar characteristics of autism
- Features may include long and narrow face. large ears prominent jaw and flat feet
- Fragile X occurs in approximately 1 in 4,000 males and 1 in 8,000 females
- Symptoms oftn often include mild to moderate intellectual disability
- Child with Fragile X tend to have short attention span
- Self-talk is common using different tones and pitches
- In 1969, Herbert Lubs first discovered an unusual markers X chromosome in association with an intellectual disability.
- In 1970, Frederick Hecht coined the term Fragile site
- In 1985 Felix F. De La Cruz outlined physical. psychological, characteristics of those
- It is inherited
- Early signs may include developmental delays such as late developmental in sitting, walking, etc.
- In 1943, James, Purdon Martin and Julia Bell described a pedigree of the x-linked mental disability
- Fragile X is caused by a mutation in a single gene.
- Fragile X is also called Martin-Bell Syndrome
- Fragile X Syndrome has been found in all major ethnic groups and races
- Fragile x is the most common form of inherited developmental disability
- Fragile X is often mis-diagnosed
- It is formally named Martin-Bell
- It was first discovered in 1943
- It is found in all races and socio-economic levels
- It varies from borderline to severe
- Diagnosis of Fragile X is due through DNA test and genetic counseling
- Fragile X changes can occur from one generation to the next
- Fragile X is inherited through the mother
