Published by: Fragile X News Today
Written by: Vijaya Iyer
Social anxiety and autistic traits are prevalent in males with fragile X syndrome and these behaviors overlap with those observed in individuals with autism spectrum disorder (ASD) without a known genetic syndrome, a study reports.
The overlap of traits between the two clinical subgroups makes their measurement extremely challenging, researchers said.
The study, “Biobehavioral composite of social aspects of anxiety in young adults with fragile X syndrome contrasted to autism spectrum disorder,” was published in the American Journal of Medical Genetics. Click here to read the rest of the story
Click here to download a PDF version
- It is a genetic condition
- Males are more affected than females
- Seizures occur in about 15% of males and 5% of females
- 1/3 individuals have similar characteristics of autism
- Features may include long and narrow face. large ears prominent jaw and flat feet
- Fragile X occurs in approximately 1 in 4,000 males and 1 in 8,000 females
- Symptoms oftn often include mild to moderate intellectual disability
- Child with Fragile X tend to have short attention span
- Self-talk is common using different tones and pitches
- In 1969, Herbert Lubs first discovered an unusual markers X chromosome in association with an intellectual disability.
- In 1970, Frederick Hecht coined the term Fragile site
- In 1985 Felix F. De La Cruz outlined physical. psychological, characteristics of those
- It is inherited
- Early signs may include developmental delays such as late developmental in sitting, walking, etc.
- In 1943, James, Purdon Martin and Julia Bell described a pedigree of the x-linked mental disability
- Fragile X is caused by a mutation in a single gene.
- Fragile X is also called Martin-Bell Syndrome
- Fragile X Syndrome has been found in all major ethnic groups and races
- Fragile x is the most common form of inherited developmental disability
- Fragile X is often mis-diagnosed
- It is formally named Martin-Bell
- It was first discovered in 1943
- It is found in all races and socio-economic levels
- It varies from borderline to severe
- Diagnosis of Fragile X is due through DNA test and genetic counseling
- Fragile X changes can occur from one generation to the next
- Fragile X is inherited through the mother